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mTOR inhibitors broadly enhance the efficacy of proteasome-dependent targeted protein degradation approaches

In January, the research team led by Professor Cang Yong from the School of Life Science and Technology (SLST) at ShanghaiTech University, in collaboration with the team led by Dr. Lu Wei from the Hematology Department of Shanghai Ninth People’s Hospital, published a paper titled “Inhibition of mTOR Enhances the Efficacy of Proteasome-Dependent Targeted Protein Degradation Approaches” in Cancer Research. The study reveals the critical role of the mTOR signaling pathway in regulating the efficacy of proteasome-dependent TPD approaches, and proposes a novel clinical translati

2026-02-03
Scientists introduce a foundation model for cervical cytology screening

A team led by Professor Wang Qian from the School of Biomedical Engineering (BME) at ShanghaiTech University has published a new study in Cell Reports Medicine. The paper, titled “UniCAS: A foundation model for cervical cytology screening,” presents a specialized AI foundation model built for automated cervical cancer screening using ThinPrep Cytology Test (TCT) slides.

2026-01-30
Dual-pathway framework overcomes the naturalness-intelligibility trade-off in reconstructing authentic speech from brain signals

Recently, the research group led by Assistant Professor Li Yuanning from the School of Biomedical Engineering (BME) at ShanghaiTech University proposed an efficient acoustic-linguistic dual-pathway framework that achieves reconstruction of sentence-level speech with both naturalness and intelligibility, using only about 20 minutes of high-density electrocorticography (ECoG, a technique that directly records electrical signals from the brain’s cortical surface) data per participant. Their results were published in eLife.

2026-01-14
Scientists reveal the pathogenic role of dysplastic epithelial cells in lymphocyte tissue residence and alveolar regeneration

On December 23, Assistant Professor Xi Ying’s lab at the School of Life Science and Technology (SLST), in collaboration with Prof. Ren Tao from Shanghai Sixth People’s Hospital and Prof. Zhao Jincun from Guangzhou Medical University/Guangzhou Laboratory, published a paper entitled “Dysplastic epithelial repair promotes the tissue-residence of lymphocytes to inhibit alveolar regeneration post viral infection” in the journal Cell Stem Cell. For the first time, this work reveals the pathogenetic role of KRT5+ pods in lung regeneration, serving as a niche for tissue-resident ly

2025-12-29
Xiang Yangfei group develops human organoid model for sympathetic-heart interaction

On December 12, Assistant Professor Xiang Yangfei’s lab at the School of Life Science and Technology (SLST) published a paper entitled “Human PSC-derived organoids model sympathetic ganglion development and its functional crosstalk with the heart” in the journal Cell Stem Cell.

2025-12-12
Scientists achieve precise and efficient RNA editing via cleavage of an ADAR inhibitor

The development of programmable, site-specific gene editing tools has provided methods and strategies for correcting pathogenic mutations, such as emerging RNA editing technologies. Unlike DNA editing, RNA editing transiently modifies RNA transcripts, thereby avoiding the long-term safety risks associated with DNA off-target effects.

2025-03-27
An efficient and precise mitochondrial adenine base editor

Mitochondria, the “powerhouses” of cells, play a vital role in adenosine triphosphate (ATP) production. Mitochondria possess their own independent DNA, termed mitochondrial DNA (mtDNA), which encodes genes essential for mitochondrial function. Compared to nuclear DNA, mtDNA is more prone to mutations due to reactive oxygen species generated during oxidative phosphorylation. Most mtDNA mutations are base substitutions, leading to mitochondrial genetic disorders such as Leber hereditary optic neuropathy (LHON), Leigh syndrome, and mitochondrial encephalomyopathy, lactic acido

2025-03-27
Unlocking the immune system switch: New study reveals how LAG3 modulates immune responses

A new study published in Cell has uncovered how a molecule called LAG3 functions as a brake to suppress the immune system. This discovery helps explain how cancer avoids immune attacks and may guide doctors to better treatment options. Led by Associate Professor Wang Haopeng from the School of Life Science and Technology (SLST) at ShanghaiTech University, this research offers a fresh perspective for improving cancer immunotherapy.

2025-03-19
SLST researchers unravel the mechanisms underlying plant proline metabolism

Abiotic stresses such as drought, salinity, and extreme temperatures threaten global crop yields. For optimum crop productivity, plants must efficiently combat these stresses. Rapid accumulation of proline under stress is a key feature and primary defense strategy in plants. Arabidopsis thaliana pyrroline-5-carboxylate synthase (AtP5CS), involved in proline metabolism, serves as the rate-limiting enzyme for de novo proline synthesis in plants. AtP5CS contains both glutamate kinase (GK) and glutamate-5-semialdehyde dehydrogenase (GPR) domains.

2024-05-27
ShanghaiTech researchers unveil the structure and inhibition mechanism of prokaryotic CTP synthase

Led by Professor Liu Ji-Long in the School of Life Science and Technology, a research team has recently made strides in comprehending the structure and inhibition mechanisms of prokaryotic cytidine triphosphate (CTP) synthase, as detailed in the academic journal mLife in a paper entitled “Filamentation and inhibition of prokaryotic CTP synthase with ligands” on May 2. This study provides novel insights into CTP synthase regulation within biological systems and lays groundwork for innovative therapeutic approaches against bacterial pathogens.

2024-05-08